Excitatory Amino Acids: Clinical Results with Antagonists Philippa H. safety aspects

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Excitatory Amino Acids: Clinical Results with Antagonists Philippa H. safety aspectsGlutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chronic pain, and schizophrenia. Excitatory amino acid receptor agonists and antagonists are therefore of major interest as potential drugs for central nervous